DAF-16/FOXO Controlled, germline Tumor affecting 11

Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased) 3

DAF-16/FOXO Controlled, germline Tumor affecting 13

DAF-16/FOXO Controlled, germline Tumor affecting 7

Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased) 2

DAF-16/FOXO Controlled, germline Tumor affecting 15

Downstream Of DAF-16 (regulated by DAF-16) 18

DAF-16/FOXO Controlled, germline Tumor affecting 17

DAF-16/FOXO Controlled, germline Tumor affecting 18

Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased) 1

Arsenic is a naturally occurring metalloid, and its pollution poses a global threat to humanity. Studies have shown that arsenic exposure accelerates aging, but the effects and mechanisms of sodium arsenite exposure on aging across both parental and ...

Cellular quiescence is a low metabolic, non-proliferative state critical for tissue maintenance and regenerative capacity, with broad implications for aging and age-related diseases. In Caenorhabditis elegans, L1 developmental arrest upon hatching in...

Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, drives aging and age related functional decline. Natural polysaccharides from medicinal plants are promising interventions against oxi...

Caenorhabditis elegans, a nematode genetic model, is often synchronized in experiments to accurately observe its unbiased phenotypes. Chemical synchronization, simple bleaching of gravid worms, has been widely used to obtain eggs in bulk because the ...

Animals must allocate limited energetic resources across competing defense programs in response to infection. Here, we show that the conserved nuclear hormone receptor NHR-68 integrates fatty acid metabolism with the neural control of molecular and b...

Bisphenol A bis(diphenyl phosphate) (BDP), an emerging oligomeric organophosphate ester, has been increasingly detected in the environment. However, its effects on host defense at environmentally relevant concentrations remain unclear. Using Caenorha...

Perilla frutescens (PF) is rich in flavonoids and other secondary metabolites with antioxidant properties. This study explored the lifespan-modulating effects and underlying mechanisms of an ethyl acetate extract of PF leaves (EAEPF) using Caenorhabd...

Aging is a progressive decline in physiological functions and the capacity to maintain homeostasis, representing a major risk factor for numerous chronic diseases. Geroprotectors, defined as natural or synthetic compounds capable of improving healths...

Erigeron breviscapus Hand-Mazz. (EBHM) is a well-documented herbal medicine with recognized antioxidant, anti-apoptotic, and anti-inflammatory bioactivities. However, its anti-senescence effects and the underlying mechanisms remain poorly understood....

Achyrocline satureioides is widely consumed as an herbal infusion in South America; however, the toxicological profile of its aqueous extract (ASAE), particularly under conditions of neurotoxic stress, remains incompletely characterized. In the prese...

For the chronic exposure (10 days) to MOX, the level of ROS was reduced due to the increased expressions of daf-16, sod-3, and hsp-16, accompanied with and the down-regulation of cep-1.

Similarly, the down-regulation of oxidative stress (sod-1 and daf-16) and cell damage (HSPs) related genes and the up-regulation of apoptosis-related genes (cep-1 and ape-1) indicated the oxidative stress and genotoxicity after prolonged exposure to MOX-Cu.

These effects were associated with upregulation of antioxidant genes (daf-16, skn-1, sod-3, gst-4, ctl-1, ctl-2).

Similarly, the down-regulation of oxidative stress (sod-1 and daf-16) and cell damage (HSPs) related genes and the up-regulation of apoptosis-related genes (cep-1 and ape-1) indicated the oxidative stress and genotoxicity after prolonged exposure to MOX-Cu.

For the chronic exposure (10 days) to MOX, the level of ROS was reduced due to the increased expressions of daf-16, sod-3, and hsp-16, accompanied with and the down-regulation of cep-1.

Meanwhile, at the exposure to MOX-Cu, the levels of ROS and lipofuscin were decreased due to the up-regulation of sod-1 and daf-16, and the antioxidant defense was promoted and confirmed by the increase of amino acids and their related metabolic pathways.

Meanwhile, acl-5 and acl-6 RNAi caused susceptibility to 6-PPDQ toxicity by upregulating the expressions of insulin ligands and receptor genes and downregulating the expressions of daf-16 and its target genes.

Meanwhile, acl-5 and acl-6 RNAi caused susceptibility to 6-PPDQ toxicity by upregulating the expressions of insulin ligands and receptor genes and downregulating the expressions of daf-16 and its target genes.

The researches using C. elegans mutant strains suggested that these effects are associated with the conserved stress response pathways DAF-16 and SOD-3, indicating potential involvement in cellular defense mechanisms.

Similarly, the down-regulation of oxidative stress (sod-1 and daf-16) and cell damage (HSPs) related genes and the up-regulation of apoptosis-related genes (cep-1 and ape-1) indicated the oxidative stress and genotoxicity after prolonged exposure to MOX-Cu.