ddl-1
WBGene00019125protein_coding_geneCaenorhabditis elegans
Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased) 1
Synonyms: CELE_F59E12.10, F59E12.10, wshc-3
Evidence (3 claims)
Supportsregulation92% conf.
HSF-1→HSF-1
This regulation occurs at an early step of HSF-1 activation via two HSF-1 regulators, DDL-1 and DDL-2.
HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity.PMID:22265419
Supportsregulation76% conf.
HSF-1→HSF-1
Furthermore, biochemical analyses suggest that DDL-1/2 negatively regulate HSF-1 activity by forming a protein complex with HSF-1.
HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity.PMID:22265419
Uncertainregulates
DDL-1→HSF-1
Furthermore, biochemical analyses suggest that DDL-1/2 negatively regulate HSF-1 activity by forming a protein complex with HSF-1.
HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity.PMID:22265419