abnormal DAuer Formation 36

abnormal DAuer Formation 10

abnormal DAuer Formation 14

abnormal DAuer Formation 4

High temperature-Induced Dauer formation 1

abnormal DAuer Formation 8

abnormal DAuer Formation 30

abnormal DAuer Formation 41

abnormal DAuer Formation 1

abnormal DAuer Formation 15

Animals are more likely to form dauers at temperatures that do not induce dauer entry in control animals.

Animals do not enter dauer at a temperature that induces dauer formation in control animals.

Animals enter the dauer stage when exposed to lower concentrations or shorter exposure times of chemicals that induce dauer formation compared to that observed in control animals.

Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals.

Animals exhibit variations in the entry into the dauer stage when exposed to concentrations of chemicals that induce dauer formation in control animals.

Animals exhibit variations in the entry into the dauer stage when exposed to nutrient poor conditions that induce dauer formation in control animals.

Animals are more likely to form dauers under nutrient conditions that do not induce dauer entry in control animals.

Animals do not enter dauer under nutrient-poor conditions that induce dauer formation in control animals.

Characteristic entry into the dauer stage is altered compared to control animals.

Animals exhibit variations in the entry into the dauer stage when exposed to temperatures that induce dauer formation in control animals. In C. elegans, many Daf-c animals enter dauer at 25C, whereas ...

Secondary bacterial metabolites can regulate animal physiology, but the specific bacterial genes and molecules responsible for regulating, synthesizing, and transporting these molecules and the mechanisms by which they impact animal physiology often ...

Background: Oxidative stress, neuroinflammation, impaired autophagy, and mitochondrial dysfunction are major contributors to ageing and neurodegenerative diseases. This study investigated whether AgeViva could counteract these processes by modulating...

Dauer formation and L1 arrest are stress-responsive developmental strategies that enable Caenorhabditis elegans to survive unfavorable conditions. These responses are regulated by environmental cues, including food availability and pheromone signals ...

Phosphatidylinositol 3-kinase (PI3K) integrates insulin/IGF signaling (IIS) and Ras inputs to control lifespan, metabolism and growth. Yet the organismal consequences of selective structural perturbations remain poorly understood. Using structure-gui...

Dauer formation, a major nematode survival strategy, represents a model for small-molecule regulation of metazoan development [1-10]. Free-living nematodes excrete dauer-inducing pheromones that have been assumed to target conspecifics of the same ge...

Nematode EAK-7 (enhancer-of-akt-1-7) regulates dauer formation and controls life span; however, the function of the human ortholog mammalian EAK-7 (mEAK-7) is unknown. We report that mEAK-7 activates an alternative mechanistic/mammalian target of rap...

V-ATPases are rotary proton pumps that serve as signaling hubs with numerous protein binding partners. CryoEM with exhaustive focused classification allowed detection of endogenous proteins associated with porcine kidney V-ATPase. An extra C subunit ...

The free-living soil nematodeCaenorhabditis elegans forms a nonfeeding dispersal stage at the second molt called the dauer larva when exposed to environmental cues indicating crowding and limited food. An improved bioassay, tenfold more sensitive tha...

Dormancy is evolutionarily widespread and can take many forms, including diapause, dauer formation, estivation, and hibernation. Each type of dormancy is characterized by distinct features; but accumulating evidence suggests that each is regulated by...

Unravelling the multifaceted and bidirectional interactions between microbiota and host physiology represents a major scientific challenge. Here, we utilise the nematode model, Pristionchus pacificus, coupled to a laboratory-simulated decay process o...

The K. aerogenes infection affects age-1 regulation through the furin-like proprotein convertase (kpc-1); the absence of kpc-1 affects environment-dependent dauer formation.

In unfavorable conditions, the DAF-16/FOXO transcription factor and the DAF-12 nuclear hormone receptor in its ligand-free state promote dauer formation and oppose the expression of let-7 family microRNAs, thus pausing developmental progression during dauer.

Unexpectedly, a putative AGE-1 variant defective in Ras association, together with a complementary Ras effector-binding mutation, produced enlarged animals with reduced dauer formation.

Furthermore, lack of ets-10p::gfp expression early in the second larval stage partially predicts which daf-16 ; daf-7 larvae will bypass dauer formation.

The K. aerogenes infection affects age-1 regulation through the furin-like proprotein convertase (kpc-1); the absence of kpc-1 affects environment-dependent dauer formation.

In unfavorable conditions, the DAF-16/FOXO transcription factor and the DAF-12 nuclear hormone receptor in its ligand-free state promote dauer formation and oppose the expression of let-7 family microRNAs, thus pausing developmental progression during dauer.

From this, we found that the effects of exogenous sugars on the phenotype of daf-2 mutant animals is dependent on the function of pyruvate dehydrogenase in bacteria and that the loss of bacterial pyruvate dehydrogenase genes (ex. aceE) is sufficient to mimic the effects of dietary sugars on dauer formation, longevity, and gene expression in insulin signaling deficient animals.

Unexpectedly, a putative AGE-1 variant defective in Ras association, together with a complementary Ras effector-binding mutation, produced enlarged animals with reduced dauer formation.

The FOXO ortholog daf-16 promotes dauer formation, but daf-16 mutants can enter dauer with incomplete penetrance in combination with a mutation in daf-7 /TGFβ.

Timed auxin-mediated depletion of DAF-16 indicated that daf-16 is required before dauer formation, rather than after dauer, to prevent reiterative seam cell fates in post-dauer larvae and adults.