Worm AIF (apoptosis inducing factor) Homolog 1

PRKC apoptosis WT1 regulator protein

Germ Line Apoptosis abnormal 3

Cytokinesis, Apoptosis, RNA-associated 1

WS Messenger RNA binding INhibitor of Apoptosis 1

Germ Line Apoptosis abnormal 1

Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, UV irradiation, compared to control.

Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals.

Any perturbation that causes an elevation in the frequency of cell death by apoptosis compared to control animals.

Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fra...

Animals exhibit a decreased pace of the programmed cell death pathway, compared to that observed for control cells.

Programmed cell death of germ cells caused by exposure to DNA-damaging chemical agents does not occur to the same extent as it does in control animals.

Animals exhibit variations in any processes that influence the programmed cell death pathway. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to th...

Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control.

Programmed cell death caused by UV radiation is reduced compared to control animals. In C. elegans, this is often measured in the pachytene region of the gonad.

Animals exhibit a decrease in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control.

Ligularia species (Asteraceae) have long been used in traditional East Asian medicine for the treatment of pain and inflammatory disorders. Although neuroprotection is not among their documented traditional indications, the close relationship among i...

Cells survive and reproduce by coping with acute or chronic exposure to a fixed elevated temperature or fluctuating temperatures. These properties are one of the main evolutionary forces and involve the heat shock response. This response is character...

Bisphenol A bis(diphenyl phosphate) (BDP), an emerging oligomeric organophosphate ester, has been increasingly detected in the environment. However, its effects on host defense at environmentally relevant concentrations remain unclear. Using Caenorha...

Synthetic musk ketone (MK) is extensively used in perfumes, cosmetics, and detergents. Due to its high lipophilicity, persistence, and limited removal efficiency in wastewater treatment, MK has been detected in various environmental matrices and huma...

Erigeron breviscapus Hand-Mazz. (EBHM) is a well-documented herbal medicine with recognized antioxidant, anti-apoptotic, and anti-inflammatory bioactivities. However, its anti-senescence effects and the underlying mechanisms remain poorly understood....

Exposure to 6-PPD quinone (6-PPDQ) causes both reproductive toxicity and metabolic disruption; however, metabolic basis of 6-PPDQ reproductive toxicity remains unclear. Folate absorption and metabolism are essential for cells by providing one-carbon ...

Bio-based plastics, such as polylactic acid, offer an alternative to petroleum-based plastics and a prospect to address the plastic pollution problem. While mounting evidence suggests that microplastics pose a human health threat, the risk posed by b...

Metabolic homeostasis depends on adaptive control of intracellular metabolite flux, yet how such control is reconfigured when canonical transport pathways fail is unknown. Here we define a conserved vesicular circuit that preserves systemic heme bala...

Programmed cell death (apoptosis) during oogenesis is conserved across metazoans and linked to regulation of oocyte number and quality. In oogenic germlines, the removal of developing oocytes by apoptosis ensures that oocytes do not contain DNA damag...

Particulate matter (PM) from vehicle exhaust represents a major air pollutant that poses potential health risks. This study characterized three types of PM: standard reference material diesel particulate matter, World Harmonized Transient Cycle diese...

Specifically, we find EOR-1/PLZF positively regulates Apoptosis Inducing Factor homolog WAH-1 during CCE.

The adverse outcome pathways revealed that BDCPP disrupted germline stem cells (GSCs) apoptosis, transmitting reproductive signals through the kri-1-daf-16-lipl-4 signaling cascade, impairing TG hydrolysis and lifespan, while TDCPP acted through a GSC-independent route.

In contrast, DNA-damage triggers a robust CEP-1/p53-dependent-induction of egl-1 throughout the germline, yet apoptosis occurs only in late pachytene cells.

Additionally, DCHP exposure led to a reduction in both the number of eggs laid and the number of fertilized eggs, which was associated with the upregulation of apoptosis-related genes (cep-1, ced-3, ced-4 and ced-9).

We show that somatic apoptosis is driven by precise, lineage-specific activation of egl-1, whereas ced-9, ced-4, and ced-3 are ubiquitously expressed.

In contrast, DNA-damage triggers a robust CEP-1/p53-dependent-induction of egl-1 throughout the germline, yet apoptosis occurs only in late pachytene cells.

Similarly, the down-regulation of oxidative stress (sod-1 and daf-16) and cell damage (HSPs) related genes and the up-regulation of apoptosis-related genes (cep-1 and ape-1) indicated the oxidative stress and genotoxicity after prolonged exposure to MOX-Cu.

Similarly, the down-regulation of oxidative stress (sod-1 and daf-16) and cell damage (HSPs) related genes and the up-regulation of apoptosis-related genes (cep-1 and ape-1) indicated the oxidative stress and genotoxicity after prolonged exposure to MOX-Cu.

Similarly, the down-regulation of oxidative stress (sod-1 and daf-16) and cell damage (HSPs) related genes and the up-regulation of apoptosis-related genes (cep-1 and ape-1) indicated the oxidative stress and genotoxicity after prolonged exposure to MOX-Cu.

Germ cell apoptosis was reduced in pmk-1(km25), mpk-1(n2521), dbl-1(wk70), and daf-2(e1370) innate immunity related-mutants compared to N2 worms after irradiation.