Evidence Engine
Gene

lin-36

WBGene00003021protein_coding_geneCaenorhabditis elegans

abnormal cell LINeage 36

Synonyms: CELE_F44B9.6, F44B9.6

lin-36 at a glance

Evidence and relationships from published C. elegans research

9Relationships
7Claims

Knowledge Graph Relationships

Outgoing (4)

lin-36not expressed inWBbt:0007809Anatomy
1 claims0 supports1 refutesrefuted
lin-36expressed inlin-36Gene
1 claims1 supportssupported
lin-36expressed inWBbt:0006748Anatomy
1 claims1 supportssupported
lin-36regulationlin-36Gene
1 claims1 supportssupported

Incoming (5)

lin-35regulateslin-36Gene
1 claims1 supports
lin-36expressed inlin-36Gene
1 claims1 supports
lin-36regulationlin-36Gene
1 claims1 supports
lin-35regulationlin-36Gene
1 claims1 supports
lin-9regulationlin-36Gene
1 claims1 supports

Evidence (7 claims)

Supportsexpressed_in
lin-36→cell

We demonstrate that lin-36 functions in and is expressed in the vulval precursor cells, establishing that the lin-36 pathway is involved in intercellular signaling.

The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.PMID:10393123
Supportsregulation99% conf.
lin-36→lin-36

We demonstrate that lin-36 functions in and is expressed in the vulval precursor cells, establishing that the lin-36 pathway is involved in intercellular signaling.

The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.PMID:10393123
Supportsregulation99% conf.
LIN-36→LIN-36

LIN-36 represses classical cell-cycle targets by promoting DREAM binding and gene body enrichment of H2A.Z, and we find that DREAM subunit EFL-1/E2F is specific for LIN-36 targets.

DREAM represses distinct targets by cooperating with different THAP domain proteins.PMID:34686342
Refutesnot_expressed_in
LIN-36→cell

LIN-36 represses classical cell-cycle targets by promoting DREAM binding and gene body enrichment of H2A.Z, and we find that DREAM subunit EFL-1/E2F is specific for LIN-36 targets.

DREAM represses distinct targets by cooperating with different THAP domain proteins.PMID:34686342
Refutesnot_expressed_in
lin-36→vulva

The Caenorhabditis elegans gene lin-36 acts to antagonize Ras-mediated vulval induction in a pathway that includes genes with products similar to the mammalian retinoblastoma (Rb) protein and the Rb-binding protein p48.

The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.PMID:10393123
Supportsexpressed_in
lin-36→lin-36

We demonstrate that lin-36 functions in and is expressed in the vulval precursor cells, establishing that the lin-36 pathway is involved in intercellular signaling.

The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.PMID:10393123
Supportspositively_regulates
LIN-36→LIN-36

LIN-36 represses classical cell-cycle targets by promoting DREAM binding and gene body enrichment of H2A.Z, and we find that DREAM subunit EFL-1/E2F is specific for LIN-36 targets.

DREAM represses distinct targets by cooperating with different THAP domain proteins.PMID:34686342

External Links