drr-2
Dietary Restriction Response (WT but not eat-2 lifespan increased) 2
Knowledge Graph Relationships
Outgoing (7)
Incoming (1)
Evidence (12 claims)
Results from our genetic analyses suggest that eIF4H/DRR-2 functions downstream of TOR, but in parallel to the S6K/PHA-4 pathway to mediate the lifespan effects of DR.
Results from our genetic analyses suggest that eIF4H/DRR-2 functions downstream of TOR, but in parallel to the S6K/PHA-4 pathway to mediate the lifespan effects of DR.
Results from our genetic analyses suggest that eIF4H/DRR-2 functions downstream of TOR, but in parallel to the S6K/PHA-4 pathway to mediate the lifespan effects of DR.
The molecular function of DRR-2 is validated by the association of DRR-2 with polysomes and by the decreased rate of protein synthesis observed in drr-2 knockdown animals.
Inhibition of drr-2 has been shown to increase longevity.
Here, we examine the role of drr-2, a DR-responsive gene recently identified, in determining the longevity of Caenorhabditis elegans.
Previous studies have also suggested that DR might trigger a regulated reduction in drr-2 expression to initiate its longevity response.
By examining the effect of increasing drr-2 expression on DR animals, we find that drr-2 is essential for a large portion of the longevity response to DR.
However, the molecular mechanisms by which drr-2 influences longevity remain unknown.
Together, our findings reveal an important role for eIF4H/drr-2 in the TOR-mediated longevity responses to DR.
Results from our genetic analyses suggest that eIF4H/DRR-2 functions downstream of TOR, but in parallel to the S6K/PHA-4 pathway to mediate the lifespan effects of DR.
Previous studies have also suggested that DR might trigger a regulated reduction in drr-2 expression to initiate its longevity response.